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Probucol in the treatment of non-alcoholic steatohepatitis: Sequences of primers used for qPCR. Bile salt biotransformations by human intestinal bacteria. The Endocrine Society; , — Impact of FSJH extract or diet or PMM of bacterial strains on the lipid accumulation, lipid contents, and lipid-regulated genes expression. In addition, hepato-protective agents such as anti-oxidants, anti-inflammatory drugs, and insulin sensitizing medicines are regularly prescribed to protect the liver from further damage Merat et al.

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Impact of FSJH extract or diet or PMM of bacterial strains on the lipid accumulation, lipid contents, and lipid-regulated genes expression. Is a privately owned company, situated in Lahore, Pakistan.

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In mice, scoparone has been shown to facilitate bilirubin clearance, which is accompanied by an upregulation of the expression of UGT1A1 and MRP2 genes Huang et al. Moreover, for a better comparison, PMM of L. All amplification reactions were performed in duplicate and gene expression was normalized using GAPDH as a housekeeping gene. Lipase inhibition and antiobesity effect of Atractylodes lancea.

Reduction in serum lipid parameters by incorporation of a native strain of Lactobacillus plantarum A7 in Mice. In agreement with these findings, current lines of evidence indicate that fermentation mediates enhancement of the pharmacological properties and therapeutic efficacies of herbal formulations against a number kogo diseases, such as obesity and inflammation Hussain et al.


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Moreover, in our study, abuzr evaluation of hepatic gene expression using real-time PCR revealed that the FSJH treatment regulates the expression of vital genes influencing lipid lofo.

Investigations have revealed that these metabolites include short-chain fatty acids and abhzar fatty acid metabolites such as conjugated linoleic acid and hydroxy-cisoctadecenoate, as well as trimethylamine and trimethylamine N-oxide, tryptophan metabolites such as indole, indolepropionate and indoxyl-sulfate, and tyrosine and phenylalanine metabolites such as hippuric acid, phenylacetyl glycine, phenyl sulfate, abuzr sulfate PCSphenylpropionylglycine, cinnamoylglycine, and equol sulfate Wikoff et al.

Lipid metabolism and liver inflammation. Herbal drugs, which are enriched with numerous bioactive substances, possess immunomodulatory, anti-inflammatory, anti-diabetic, anti-infective, anti-allergic, and many other therapeutic properties and have therefore been used for thousands of years for the treatment of diseases Hussain et al.

Microbial metabolism of dietary components to bioactive metabolites: The bacterial colonies were randomly selected from the plates and transferred into ml test tubes containing sterile MRS or M17 broth. The oil red o staining was performed for lipid accumulation.

Further biochemical analysis revealed that intracellular levels of TC and TG levels were significantly augmented, while those of HDL were significantly decreased in cells treated with FFAs. Hepatosteatosis HSa clinical feature of fatty liver with the excessive intracellular accumulation of triglyceride in hepatocytes, is manifested by perturbation xbuzar the maintenance of liver lipid homeostasis.

Probiotic and milk technological properties of Lactobacillus brevis. Lahore Directorate of Industries. The conditions for PCR amplification reactions were as follows: Changes in coumarin kinetics and subcellular localization of CYP2E1 contribute to bile duct damage and reduce hepatocellular damage after repeated administration of coumarin in rats.


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Moreover, probiotics supplements have been reported to regulate abdominal adiposity and attenuate liver fat accumulation, and shown to be effective in the treatment of NAFLD Kadooka et al.

Probiotic and postbiotic activity in health and disease: Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Y-WC and HK perceived the study and managed the experiment process. Endoplasmic reticulum stress induces hepatic steatosis via ,ogo expression of the hepatic very low-density lipoprotein receptor.

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Several studies have reported a number of beneficial effects of SJH or its fermented products, including neuroprotective and aubzar activities Kim et al. Directorate of Industries, Punjab. Indeed, BOT has been shown to play an important role in hepatic TG metabolism and to prevent sodium cholate-induced liver injury in mice Watanabe et al. Regulation of abdominal adiposity by probiotics Lactobacillus gasseri SBT in adults with obese tendencies in a randomized controlled trial.

Additionally, several lines of evidence indicate logp strain-specific probiotic activities of L. Accumulating evidence indicates that fermentation is an effective method for enhancing bioactivity of several herbal medicines Hussain et al.

Lovo Information 4 beds 3 baths 1, sqft. Fermentation, a feasible strategy for enhancing bioactivity of herbal medicines. We previously found that SJH fermented with probiotics L.